ABSTRACT
Objective To compare performance of children with attention deficit hyperactivity disorders-combined (ADHD-C) type with control children in multi-source interference task (MSIT) evaluated by means of error related negativity (ERN). Method We studied 12 children with ADHD-C type with a median age of 7 years, control children were age- and gender-matched. Children performed MSIT and simultaneous recording of ERN. Results We found no differences in MSIT parameters among groups. We found no differences in ERN variables between groups. We found a significant association of ERN amplitude with MSIT in children with ADHD-C type. Some correlation went in positive direction (frequency of hits and MSIT amplitude), and others in negative direction (frequency of errors and RT in MSIT). Conclusion Children with ADHD-C type exhibited a significant association between ERN amplitude with MSIT. These results underline participation of a cingulo-fronto-parietal network and could help in the comprehension of pathophysiological mechanisms of ADHD. .
Objetivo Comparar el rendimiento de un grupo de niños con trastorno por déficit de atención-hiperactividad de tipo combinado (TDAH-C), con niños controles, en la tarea de interferencia multi-fuente (TIMF), evaluado por la negatividad relacionada al error (NRE). Método Estudiamos 12 niños con TDAH-C con una mediana de 7 años, los controles estuvieron pareados por edad y género. Los niños realizaron la TIMF con registros simultáneos de NRE. Resultados No encontramos diferencias en los parámetros de la TIMF entre grupos. No encontramos diferencias en las variables de la NRE entre grupos. Encontramos asociaciones significativas entre la amplitud de la NRE en niños con TDAH-C. Una correlación fue en dirección positiva: (frecuencia de aciertos y amplitud de TIMF), y otras fueron en dirección negativa (frecuencia de errores y el tiempo de respuesta en la TIMF). Conclusión Los niños con TDAH-C presentan una asociación significativa entre la amplitud de la NRE con la TIMF. Los resultados sugieren la participación de la red cíngulo-fronto-parietal y pueden ayudar en la comprensión de los mecanismos fisiopatológicos del TDAH-C. .
Subject(s)
Aged , Female , Humans , Male , Cystectomy , Obesity/complications , Postoperative Complications/epidemiology , Postoperative Complications/etiology , Body Mass Index , Propensity Score , Risk Assessment , Treatment OutcomeABSTRACT
INTRODUCTION: Epilepsy is considered a health problem. 85% of patients are satisfactorily controlled with antiepileptic drugs (AEDs) and 15% have refractory seizures. The combination of omega 3 and omega 6 fatty acids (EquazenTM) can contribute to changes in ionic currents and to stabilization of neurotransmitter's function resulting in cell membrane equilibrium. These changes lead to potential seizure control. OBJECTIVE: To compare efficacy and safety in the treatment of refractory epilepsy with a supplement combining EPA, DHA (omega 3 fatty acids) and GLA (omega 6 fatty acids). METHODS: We reviewed patients from the Neurology Department of the Children's Hospital of Mexico who have refractory epilepsy, evaluating clinical characteristics of seizures, number of seizures and AEDs. 792 mg of EPA, DHA and GLA per day (6 capsules of EquazenTM) were administrated for four weeks in order to assess the frequency of seizures as well as tolerability and probable side effects. RESULTS: The study was conducted with a total of 13 patients with follow-up four weeks after the start of supplementation. We obtained a satisfactory clinical response with ≥ 80% decrease in the daily number of seizures in more than 60% of patient. The mean of number of seizures over all patients was reduced significantly from 26.61±37.2 to 5.92 daily. In addition a significant improvement in the neurocognitive capacity was observedin all patients. CONCLUSION: The co-adjuvant supplementation with EquazenTM may result in a reduction of the number of seizures in refractory epilepsy having in addition significant impact on neurocognitive aspects. To enhance the quality of life of epileptic patient supplementation with a specific combination of EPA, DHA and GLA should be reconsidered.
INTRODUÇÃO: epilepsia é considerada um problema de saúde em que 85% dos pacientes são satisfatoriamente controlados com drogas antiepilépticas (DAE) e 15% tem crises refratárias. A combinação de ácidos graxos ômega 3 e ômega 6 (EquazenTM) pode contribui em mudanças em correntes iônicas e estabilização de neurotransmissores, resultando em equilíbrio da membrana celular. Estas mudanças levam a potencial controle de crises. OBJETIVO: comparar a eficácia e segurança suplementos combinando EPA, DHA (ácidos graxos ômega 3) e GLA (ácidos graxos ômega 6) no tratamento da epilepsia refrataria. MÉTODOS: crianças com epilepsia refratária do Departamento de Neurologia do Hospital Infantil do México tiveram avaliadas as características de suas crises, frequência e numero de DAEs. EPA, DHA e GLA (6 capsulas de Equazem - 729mg) foram administrados em um período de 4 semanas, sendo acessados tolerabilidade, efeitos colaterais e frequência de crises. RESULTADOS: 13 pacientes foram avaliados por 4 semanas após o início da suplementação. Um controle clínico satisfatório (redução de 80% ou mais das crises) foi obtido em 60% dos pacientes (26.61±37.2 crises para 5.92 crises ao dia), além de significativa melhora em sua capacidade neurocognitiva. CONCLUSÃO: a suplementação de Equazen pode determinar redução no número de crises em epilepsia refratária e determinar melhora em parâmetros neurocognitivos. O uso da combinação EPA, DHA, GLA deveria ser reconsiderado neste cenário.